/* ============================================================================
   The CRISPR Atlas — visual identity
   Dark "deep genome" default with a paper-white light mode.
   Type: Sora (display) · Inter (UI) · Newsreader (article body) · IBM Plex Mono
   (sequence + data). Motif: genomic map tracks, chromosome bands, base-pair
   rules. No generic double-helix wallpaper anywhere.
   ========================================================================== */

@font-face{font-family:Sora;src:url(/static/fonts/Sora.woff2)format("woff2");font-weight:100 800;font-display:swap}
@font-face{font-family:InterV;src:url(/static/fonts/Inter-400.woff2)format("woff2");font-weight:100 900;font-display:swap}
@font-face{font-family:Newsreader;src:url(/static/fonts/Newsreader.woff2)format("woff2");font-weight:200 800;font-display:swap}
@font-face{font-family:Newsreader;src:url(/static/fonts/NewsreaderItalic.woff2)format("woff2");font-weight:200 800;font-style:italic;font-display:swap}
@font-face{font-family:PlexMono;src:url(/static/fonts/PlexMono-400.woff2)format("woff2");font-weight:400;font-display:swap}
@font-face{font-family:PlexMono;src:url(/static/fonts/PlexMono-600.woff2)format("woff2");font-weight:600;font-display:swap}

:root{
  --bg:#050912; --bg2:#0a1020; --panel:#0d1424; --panel2:#111a2e; --panel3:#16203a;
  --line:#1d2942; --line2:#27364f;
  --ink:#e9eef9; --ink2:#a6b3cc; --ink3:#6e7d9a;
  --blue:#4f8bff; --teal:#2ee3c3; --violet:#a98bff; --amber:#ffb454;
  --green:#45d483; --red:#ff6f6f; --pink:#ff7fc4;
  --a:#2ee3c3; --c:#4f8bff; --g:#a98bff; --tt:#ffb454;      /* base-pair colours */
  --shadow:0 18px 50px rgba(0,0,0,.55);
  --radius:14px;
  --f-d:Sora,ui-sans-serif,system-ui,sans-serif;
  --f-b:InterV,ui-sans-serif,system-ui,-apple-system,sans-serif;
  --f-r:Newsreader,Georgia,"Times New Roman",serif;
  --f-m:PlexMono,ui-monospace,SFMono-Regular,Menlo,monospace;
  --max:1280px;
}
:root[data-theme=light]{
  --bg:#f7f9fc; --bg2:#eef2f8; --panel:#ffffff; --panel2:#f4f7fb; --panel3:#e9eff7;
  --line:#dce4ef; --line2:#c8d4e4;
  --ink:#0c1424; --ink2:#41506b; --ink3:#6b7c98;
  --blue:#1f5fe0; --teal:#0f9c86; --violet:#6f4fd8; --amber:#b8720a;
  --green:#17924f; --red:#cf3b3b; --pink:#c03d8c;
  --a:#0f9c86; --c:#1f5fe0; --g:#6f4fd8; --tt:#b8720a;
  --shadow:0 12px 34px rgba(18,32,60,.10);
}

*{box-sizing:border-box}
html{-webkit-text-size-adjust:100%}
body{
  margin:0;background:var(--bg);color:var(--ink);font-family:var(--f-b);
  font-size:16px;line-height:1.6;-webkit-font-smoothing:antialiased;
  overflow-x:hidden;
}
/* the ambient genomic field behind everything */
#genome{position:fixed;inset:0;width:100%;height:100%;z-index:0;opacity:.5;pointer-events:none}
:root[data-theme=light] #genome{opacity:.30}
body>header,body>main,body>footer,body>.offcanvas,body>.oc-backdrop{position:relative;z-index:1}

a{color:var(--blue);text-decoration:none}
a:hover{text-decoration:underline}
img{max-width:100%;display:block}
h1,h2,h3,h4{font-family:var(--f-d);font-weight:700;line-height:1.15;letter-spacing:-.02em;margin:0 0 .5em}
h1{font-size:clamp(1.9rem,4.4vw,3.1rem)}
h2{font-size:clamp(1.35rem,2.6vw,2rem)}
h3{font-size:1.12rem}
p{margin:0 0 1em}
:focus-visible{outline:2px solid var(--teal);outline-offset:2px;border-radius:6px}
.skip{position:absolute;left:-9999px}
.skip:focus{left:12px;top:8px;z-index:99;background:var(--panel);padding:8px 14px;border-radius:8px;border:1px solid var(--line2)}

/* ---------------------------------------------------------------- topbar -- */
.topbar{
  display:flex;align-items:center;gap:14px;padding:9px 18px;
  background:color-mix(in srgb,var(--bg) 88%,transparent);
  backdrop-filter:blur(14px);border-bottom:1px solid var(--line);
  position:sticky;top:0;z-index:60;
}
.burger{display:none;background:none;border:0;color:var(--ink);font-size:1.3rem;cursor:pointer;padding:4px 6px}
.logo-wrap{display:flex;flex-direction:column;flex:0 0 auto;min-width:auto}
.logo{font-family:var(--f-d);font-weight:700;font-size:1.06rem;color:var(--ink);letter-spacing:-.02em;white-space:nowrap;display:flex;align-items:center;gap:8px}
.logo:hover{text-decoration:none}
.logo span{color:var(--teal)}
.logo-mark{width:22px;height:22px;flex:0 0 auto}
.tagline{font-size:.685rem;color:var(--ink3);white-space:nowrap;letter-spacing:.02em}
.mainnav{display:flex;align-items:center;gap:2px;margin-left:6px;flex:1 1 auto}
.mainnav>a,.ddbtn{color:var(--ink2);padding:8px 9px;border-radius:8px;font-size:.855rem;white-space:nowrap;font-weight:500}
.mainnav>a:hover,.ddbtn:hover{background:var(--panel2);color:var(--ink);text-decoration:none}
.dd{position:relative}
.ddmenu{display:none;position:absolute;top:calc(100% + 8px);left:0;background:var(--panel);border:1px solid var(--line2);border-radius:12px;padding:10px;min-width:230px;box-shadow:var(--shadow);z-index:70}
.ddmenu.open{display:block}
.ddmenu a{display:block;padding:7px 10px;border-radius:8px;color:var(--ink2);font-size:.87rem}
.ddmenu a:hover{background:var(--panel3);color:var(--ink);text-decoration:none}
.ddmega{display:none;grid-template-columns:repeat(4,minmax(160px,1fr));gap:6px;min-width:min(860px,92vw)}
.ddmega.open{display:grid}
.ddcol b{display:block;font-family:var(--f-d);font-size:.68rem;letter-spacing:.14em;text-transform:uppercase;color:var(--teal);padding:6px 10px 3px}
.searchwrap{position:relative;flex:0 1 250px;margin-left:auto}
.searchwrap input,.hero-search input{
  width:100%;background:var(--panel2);border:1px solid var(--line2);border-radius:10px;
  color:var(--ink);padding:8px 12px;font:inherit;font-size:.86rem;
}
.searchwrap input::placeholder{color:var(--ink3)}
.searchresults{display:none;position:absolute;top:calc(100% + 6px);left:0;right:0;background:var(--panel);border:1px solid var(--line2);border-radius:12px;box-shadow:var(--shadow);max-height:60vh;overflow:auto;z-index:80}
.searchresults.open{display:block}
.searchresults a{display:flex;justify-content:space-between;gap:12px;padding:9px 13px;color:var(--ink);font-size:.87rem;border-bottom:1px solid var(--line)}
.searchresults a:last-child{border-bottom:0}
.searchresults a:hover{background:var(--panel3);text-decoration:none}
.searchresults .k{color:var(--ink3);font-size:.7rem;text-transform:uppercase;letter-spacing:.08em;white-space:nowrap;font-family:var(--f-d)}
.savebtn,.theme-toggle{background:none;border:1px solid var(--line2);border-radius:9px;color:var(--ink2);cursor:pointer;padding:6px 9px;font-size:.95rem;line-height:1;position:relative}
.savebtn:hover,.theme-toggle:hover{color:var(--teal);border-color:var(--teal);text-decoration:none}
.favbadge{position:absolute;top:-6px;right:-6px;background:var(--teal);color:#04121a;border-radius:9px;font-size:.6rem;padding:1px 5px;font-weight:700;font-family:var(--f-d)}

/* ------------------------------------------------------------ offcanvas -- */
.offcanvas{position:fixed;top:0;bottom:0;width:min(330px,86vw);background:var(--panel);border-right:1px solid var(--line2);padding:16px;overflow-y:auto;transform:translateX(-102%);transition:transform .22s ease;z-index:120}
.offcanvas.right{right:0;left:auto;border-right:0;border-left:1px solid var(--line2);transform:translateX(102%)}
.offcanvas.open{transform:none}
.oc-head{display:flex;justify-content:space-between;align-items:center;margin-bottom:10px;font-family:var(--f-d)}
.oc-close{background:none;border:0;color:var(--ink2);font-size:1.5rem;cursor:pointer;line-height:1}
.oc-link{display:block;padding:9px 4px;color:var(--ink);border-bottom:1px solid var(--line);font-weight:600}
.offcanvas details{border-bottom:1px solid var(--line);padding:5px 0}
.offcanvas summary{cursor:pointer;padding:6px 4px;font-weight:600;font-family:var(--f-d);font-size:.94rem}
.offcanvas details a{display:block;padding:6px 4px 6px 14px;color:var(--ink2);font-size:.88rem}
.oc-row{display:flex;justify-content:space-between;align-items:center;gap:10px;padding:12px 2px;border-bottom:1px solid var(--line)}
.oc-view{background:var(--panel2);border:1px solid var(--line);border-radius:12px;padding:12px;margin:12px 0;font-size:.84rem;color:var(--ink2)}
.oc-view p{margin:0 0 .7em}
.oc-backdrop{display:none;position:fixed;inset:0;background:rgba(2,5,12,.6);z-index:110}
.oc-backdrop.open{display:block}
.lang-sel{background:var(--panel2);color:var(--ink);border:1px solid var(--line2);border-radius:8px;padding:6px 8px;font:inherit;font-size:.83rem}

/* --------------------------------------------------------------- layout -- */
.page{max-width:var(--max);margin:0 auto;padding:26px 18px 60px}
.page.wide{max-width:1480px}
.wrap{max-width:var(--max);margin:0 auto}
.sec{margin:52px 0}
.sec-head{display:flex;align-items:flex-end;justify-content:space-between;gap:16px;margin-bottom:18px;flex-wrap:wrap}
.sec-head h2{margin:0}
.sec-head p{margin:.3em 0 0;color:var(--ink2);font-size:.92rem;max-width:70ch}
.kicker{font-family:var(--f-d);font-size:.67rem;letter-spacing:.18em;text-transform:uppercase;color:var(--teal);margin:0 0 .45em;font-weight:600}
.lede{font-size:1.08rem;color:var(--ink2);max-width:74ch}
.muted{color:var(--ink3)}
.small{font-size:.82rem}
.fineprint{font-size:.74rem;color:var(--ink3)}
.center{text-align:center}
.mono{font-family:var(--f-m)}

/* base-pair rule: the signature divider */
.bprule{height:6px;border-radius:3px;margin:26px 0;
  background:repeating-linear-gradient(90deg,
    var(--a) 0 7px, transparent 7px 14px, var(--c) 14px 21px, transparent 21px 28px,
    var(--g) 28px 35px, transparent 35px 42px, var(--tt) 42px 49px, transparent 49px 56px);
  opacity:.45}

/* ----------------------------------------------------------------- hero -- */
.hero{position:relative;border-radius:20px;overflow:hidden;border:1px solid var(--line2);margin-bottom:34px;background:var(--panel)}
.hero-img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover;z-index:0}
.hero::after{content:"";position:absolute;inset:0;z-index:1;
  background:linear-gradient(105deg,rgba(4,8,18,.94) 0%,rgba(4,8,18,.82) 42%,rgba(4,8,18,.38) 72%,rgba(4,8,18,.2) 100%)}
:root[data-theme=light] .hero::after{background:linear-gradient(105deg,rgba(3,8,20,.9) 0%,rgba(3,8,20,.74) 45%,rgba(3,8,20,.35) 75%,rgba(3,8,20,.18) 100%)}
.hero-in{position:relative;z-index:2;padding:clamp(30px,5vw,62px) clamp(20px,4vw,54px);max-width:min(780px,92%)}
.hero h1{color:#fff;margin-bottom:.3em;text-shadow:0 2px 26px rgba(0,0,0,.5)}
.hero .hero-sub{color:#dbe5f6;font-size:clamp(1rem,1.5vw,1.2rem);max-width:60ch;margin-bottom:1.1em}
.hero .kicker{color:var(--teal)}
.hero.small .hero-in{padding:clamp(22px,3.4vw,40px) clamp(18px,3vw,40px)}
.hero-search{position:relative;max-width:620px;margin-top:6px}
.hero-search input{padding:15px 18px;font-size:1rem;border-radius:12px;background:rgba(9,15,28,.86);border-color:#33456a;color:#fff}
.hero-search input::placeholder{color:#8fa0bf}
.hero-ex-row{display:flex;flex-wrap:wrap;gap:7px;margin-top:12px}
.hero-ex{background:rgba(255,255,255,.09);border:1px solid rgba(255,255,255,.2);color:#e6edfb;border-radius:20px;padding:5px 12px;font:inherit;font-size:.78rem;cursor:pointer}
.hero-ex:hover{background:rgba(46,227,195,.18);border-color:var(--teal)}

/* ---------------------------------------------------------------- cards -- */
.grid{display:grid;gap:16px}
.g2{grid-template-columns:repeat(auto-fit,minmax(300px,1fr))}
.g3{grid-template-columns:repeat(auto-fill,minmax(268px,1fr))}
.g4{grid-template-columns:repeat(auto-fill,minmax(215px,1fr))}
.g5{grid-template-columns:repeat(auto-fill,minmax(178px,1fr))}

.card{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);padding:18px;display:block;color:var(--ink);transition:border-color .16s,transform .16s}
a.card:hover{border-color:var(--teal);text-decoration:none;transform:translateY(-2px)}
.card h3{margin:0 0 .35em}
.card p{margin:0;color:var(--ink2);font-size:.88rem}

/* image card — text sits ON the photo */
.icard{position:relative;border-radius:var(--radius);overflow:hidden;border:1px solid var(--line);display:block;color:#fff;min-height:186px;background:var(--panel2)}
.icard img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover;transition:transform .5s ease}
a.icard:hover img{transform:scale(1.055)}
a.icard:hover{text-decoration:none;border-color:var(--teal)}
.icard::after{content:"";position:absolute;inset:0;background:linear-gradient(to top,rgba(4,8,18,.95) 0%,rgba(4,8,18,.66) 42%,rgba(4,8,18,.18) 100%)}
.icard-in{position:relative;z-index:2;padding:16px;display:flex;flex-direction:column;justify-content:flex-end;min-height:186px}
.icard-in b{font-family:var(--f-d);font-size:1.02rem;display:block;margin-bottom:2px;text-shadow:0 1px 12px rgba(0,0,0,.6)}
.icard-in span{font-size:.8rem;color:#c6d2e8;line-height:1.4}
.icard.tall .icard-in,.icard.tall{min-height:250px}
.icard.short .icard-in,.icard.short{min-height:150px}

/* entity row / list */
.rowlist{border:1px solid var(--line);border-radius:var(--radius);overflow:hidden;background:var(--panel)}
.erow{display:flex;align-items:center;gap:14px;padding:13px 16px;border-bottom:1px solid var(--line);color:var(--ink)}
.erow:last-child{border-bottom:0}
.erow:hover{background:var(--panel2);text-decoration:none}
.erow-main{flex:1 1 auto;min-width:0}
.erow-main b{display:block;font-weight:600}
.erow-main span{display:block;color:var(--ink2);font-size:.83rem;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}
.erow-meta{flex:0 0 auto;text-align:right;font-size:.78rem;color:var(--ink3)}
.favstar{background:none;border:0;color:var(--amber);cursor:pointer;font-size:1.05rem;line-height:1;padding:2px 4px;flex:0 0 auto}

/* ---------------------------------------------------------------- chips -- */
.chip{display:inline-flex;align-items:center;gap:5px;font-family:var(--f-d);font-size:.66rem;font-weight:600;letter-spacing:.07em;text-transform:uppercase;padding:3px 9px;border-radius:20px;border:1px solid var(--line2);color:var(--ink2);background:var(--panel2);white-space:nowrap}
.chip.approved{color:var(--green);border-color:color-mix(in srgb,var(--green) 45%,transparent);background:color-mix(in srgb,var(--green) 12%,transparent)}
.chip.p3{color:var(--teal);border-color:color-mix(in srgb,var(--teal) 45%,transparent);background:color-mix(in srgb,var(--teal) 12%,transparent)}
.chip.p2{color:var(--blue);border-color:color-mix(in srgb,var(--blue) 45%,transparent);background:color-mix(in srgb,var(--blue) 12%,transparent)}
.chip.p1{color:var(--violet);border-color:color-mix(in srgb,var(--violet) 45%,transparent);background:color-mix(in srgb,var(--violet) 12%,transparent)}
.chip.pre{color:var(--amber);border-color:color-mix(in srgb,var(--amber) 45%,transparent);background:color-mix(in srgb,var(--amber) 12%,transparent)}
.chip.disc{color:var(--ink3)}
.chip.stop{color:var(--red);border-color:color-mix(in srgb,var(--red) 45%,transparent);background:color-mix(in srgb,var(--red) 12%,transparent)}
.chiprow{display:flex;flex-wrap:wrap;gap:6px;margin:0 0 12px}

/* evidence tier callout */
.evidence{display:flex;gap:10px;align-items:flex-start;border-radius:12px;padding:11px 14px;font-size:.85rem;border:1px solid var(--line2);background:var(--panel2);margin:0 0 18px}
.evidence b{font-family:var(--f-d);font-size:.7rem;letter-spacing:.1em;text-transform:uppercase}
.evidence.approved{border-color:color-mix(in srgb,var(--green) 40%,transparent);background:color-mix(in srgb,var(--green) 9%,transparent)}
.evidence.approved b{color:var(--green)}
.evidence.clinical{border-color:color-mix(in srgb,var(--teal) 40%,transparent);background:color-mix(in srgb,var(--teal) 9%,transparent)}
.evidence.clinical b{color:var(--teal)}
.evidence.preclinical{border-color:color-mix(in srgb,var(--amber) 40%,transparent);background:color-mix(in srgb,var(--amber) 9%,transparent)}
.evidence.preclinical b{color:var(--amber)}
.evidence.lab{border-color:var(--line2)}
.evidence.lab b{color:var(--violet)}
.evidence.future b{color:var(--ink3)}

/* -------------------------------------------------------------- article -- */
.article{max-width:none}
.prose{font-family:var(--f-r);font-size:1.115rem;line-height:1.72;color:var(--ink)}
.prose p{margin:0 0 1.05em}
.prose h2{font-family:var(--f-d);font-size:1.42rem;margin:1.9em 0 .55em;padding-top:.2em}
.prose h3{font-family:var(--f-d);font-size:1.1rem;margin:1.5em 0 .4em}
.prose ul,.prose ol{margin:0 0 1.1em;padding-left:1.25em}
.prose li{margin:.3em 0}
.prose a{border-bottom:1px solid color-mix(in srgb,var(--blue) 40%,transparent)}
.prose strong{font-weight:600}
.prose blockquote{margin:1.4em 0;padding:2px 0 2px 18px;border-left:3px solid var(--teal);color:var(--ink2);font-style:italic}
.tnote{background:var(--panel2);border:1px solid var(--line);border-left:3px solid var(--violet);border-radius:10px;padding:12px 15px;margin:1.3em 0;font-family:var(--f-b);font-size:.9rem;color:var(--ink2)}
.tnote b{color:var(--violet);font-family:var(--f-d);font-size:.72rem;letter-spacing:.1em;text-transform:uppercase;display:block;margin-bottom:3px}

.simple-box{background:linear-gradient(135deg,color-mix(in srgb,var(--teal) 11%,var(--panel)),var(--panel));border:1px solid color-mix(in srgb,var(--teal) 35%,var(--line));border-radius:14px;padding:18px 20px;margin:0 0 22px}
.simple-box .kicker{margin-bottom:.4em}
.simple-box p{margin:0;font-size:1.02rem;color:var(--ink)}
.deeper{border-top:1px solid var(--line);margin-top:26px;padding-top:6px}

/* layout: article + sidebar */
.split{display:grid;grid-template-columns:minmax(0,1fr) 330px;gap:34px;align-items:start}
.side{position:sticky;top:74px;display:flex;flex-direction:column;gap:16px}
.side .card{padding:15px}
.side h3{font-size:.76rem;letter-spacing:.13em;text-transform:uppercase;color:var(--teal);font-family:var(--f-d);margin-bottom:.7em}
.side ul{margin:0;padding:0;list-style:none}
.side li{padding:5px 0;border-bottom:1px solid var(--line);font-size:.87rem}
.side li:last-child{border-bottom:0}

/* fact table */
.facts{width:100%;border-collapse:collapse;font-size:.9rem}
.facts th,.facts td{text-align:left;padding:9px 10px;border-bottom:1px solid var(--line);vertical-align:top}
.facts th{color:var(--ink3);font-weight:500;width:42%;font-size:.82rem}
.facts td{color:var(--ink)}
.facts tr:last-child th,.facts tr:last-child td{border-bottom:0}
.facts .fnote{display:block;color:var(--ink3);font-size:.74rem;margin-top:2px}

/* data tables */
.tbl-wrap{overflow-x:auto;border:1px solid var(--line);border-radius:var(--radius);background:var(--panel)}
table.data{width:100%;border-collapse:collapse;font-size:.875rem;min-width:640px}
table.data th{position:sticky;top:0;background:var(--panel3);color:var(--ink2);text-align:left;padding:10px 12px;font-size:.72rem;letter-spacing:.08em;text-transform:uppercase;font-family:var(--f-d);white-space:nowrap;z-index:2}
table.data.sortable th{cursor:pointer}
table.data td{padding:10px 12px;border-top:1px solid var(--line);vertical-align:top}
table.data tbody tr:hover{background:var(--panel2)}
table.data td.num{text-align:right;font-family:var(--f-m);font-size:.83rem;white-space:nowrap}

/* mobile: tables become cards */
@media(max-width:720px){
  table.data.stack,table.data.stack thead,table.data.stack tbody,table.data.stack tr,table.data.stack td{display:block;width:100%;min-width:0}
  table.data.stack thead{display:none}
  table.data.stack tr{border:1px solid var(--line);border-radius:12px;margin-bottom:10px;background:var(--panel);padding:6px 4px}
  table.data.stack td{border:0;padding:6px 12px;display:flex;justify-content:space-between;gap:14px;text-align:right}
  table.data.stack td::before{content:attr(data-l);color:var(--ink3);font-size:.72rem;text-transform:uppercase;letter-spacing:.06em;font-family:var(--f-d);text-align:left;flex:0 0 auto}
  table.data.stack td.num{text-align:right}
  .tbl-wrap{border:0;background:none;overflow:visible}
}

/* ------------------------------------------------------------- numbers -- */
.stats{display:grid;grid-template-columns:repeat(auto-fit,minmax(150px,1fr));gap:12px}
.stat{background:var(--panel);border:1px solid var(--line);border-radius:14px;padding:16px;text-align:center}
.stat b{display:block;font-family:var(--f-d);font-size:clamp(1.5rem,3.2vw,2.1rem);color:var(--teal);line-height:1.1}
.stat span{display:block;font-size:.79rem;color:var(--ink2);margin-top:4px}
.stat em{display:block;font-style:normal;font-size:.66rem;color:var(--ink3);margin-top:5px}

/* trust strip */
.trust{display:flex;flex-wrap:wrap;gap:10px 26px;align-items:center;justify-content:center;padding:13px 18px;border:1px solid var(--line);border-radius:12px;background:var(--panel);font-size:.8rem;color:var(--ink2)}
.trust b{color:var(--ink);font-family:var(--f-d)}

/* --------------------------------------------------------------- pills -- */
.filters{display:flex;flex-wrap:wrap;gap:8px;margin:0 0 18px}
.pill{border:1px solid var(--line2);background:var(--panel);color:var(--ink2);border-radius:20px;padding:6px 13px;font-size:.8rem;cursor:pointer;font:inherit;font-size:.8rem}
.pill:hover{border-color:var(--teal);color:var(--ink);text-decoration:none}
.pill.on{background:var(--teal);border-color:var(--teal);color:#04121a;font-weight:600}
.tbtn{background:var(--teal);color:#04121a;border:0;border-radius:10px;padding:10px 17px;font:inherit;font-weight:600;cursor:pointer;font-family:var(--f-d);font-size:.88rem}
.tbtn:hover{filter:brightness(1.08);text-decoration:none}
.tbtn.ghost{background:none;border:1px solid var(--line2);color:var(--ink)}
.tbtn.ghost:hover{border-color:var(--teal);color:var(--teal)}
.btnrow{display:flex;flex-wrap:wrap;gap:10px;align-items:center}
input[type=text],input[type=email],input[type=search],input[type=number],select,textarea{
  background:var(--panel2);border:1px solid var(--line2);border-radius:10px;color:var(--ink);padding:9px 12px;font:inherit;font-size:.9rem;max-width:100%}
label{font-size:.83rem;color:var(--ink2)}

/* ------------------------------------------------------------ pipeline -- */
.pipe{display:flex;gap:3px;align-items:stretch;border-radius:9px;overflow:hidden;border:1px solid var(--line);min-height:30px}
.pipe span{flex:1 1 0;font-size:.62rem;font-family:var(--f-d);letter-spacing:.05em;text-transform:uppercase;display:flex;align-items:center;justify-content:center;background:var(--panel2);color:var(--ink3);padding:5px 3px;text-align:center}
.pipe span.on{background:color-mix(in srgb,var(--teal) 26%,var(--panel));color:var(--ink)}
.pipe span.now{background:var(--teal);color:#04121a;font-weight:700}

/* -------------------------------------------------------------- diagram -- */
.diagram{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);padding:18px;margin:1.6em 0}
.diagram svg{width:100%;height:auto;display:block}
.diagram figcaption{font-size:.8rem;color:var(--ink3);margin-top:11px;font-family:var(--f-b)}
.dg-label{font-family:var(--f-d);font-size:11px;fill:var(--ink2)}
.dg-title{font-family:var(--f-d);font-size:13px;font-weight:700;fill:var(--ink)}
.dg-mono{font-family:var(--f-m);font-size:11px;fill:var(--ink2)}

/* sequence display */
.seq{font-family:var(--f-m);font-size:.95rem;letter-spacing:.09em;background:var(--panel2);border:1px solid var(--line);border-radius:10px;padding:11px 13px;overflow-x:auto;white-space:nowrap}
.seq .bA{color:var(--a)}.seq .bC{color:var(--c)}.seq .bG{color:var(--g)}.seq .bT{color:var(--tt)}
.seq .hl{background:color-mix(in srgb,var(--teal) 26%,transparent);border-radius:3px;padding:1px 0}
.seq .pam{background:color-mix(in srgb,var(--amber) 30%,transparent);border-radius:3px;padding:1px 0}

/* --------------------------------------------------------------- images -- */
figure.fig{margin:1.8em 0}
figure.fig img{border-radius:var(--radius);border:1px solid var(--line);width:100%}
figure.fig figcaption{font-size:.79rem;color:var(--ink3);margin-top:9px;font-family:var(--f-b)}
.imgcredit{font-size:.7rem;color:var(--ink3);margin-top:6px}

/* ---------------------------------------------------------------- news -- */
.newscard{display:flex;flex-direction:column;background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);overflow:hidden;height:100%}
.newscard:hover{border-color:var(--teal);text-decoration:none}
.newscard .nc-body{padding:14px 15px;display:flex;flex-direction:column;gap:6px;flex:1}
.newscard b{font-size:.94rem;font-weight:600;color:var(--ink);line-height:1.35}
.newscard .nc-meta{font-size:.72rem;color:var(--ink3);display:flex;gap:8px;flex-wrap:wrap;margin-top:auto;padding-top:6px}
.newscard .nc-pub{color:var(--teal);font-weight:600}
.nc-ents{display:flex;flex-wrap:wrap;gap:5px;margin-top:8px}
.nc-ents a{font-size:.68rem;border:1px solid var(--line2);border-radius:20px;padding:2px 8px;color:var(--ink2)}
.nc-ents a:hover{border-color:var(--teal);color:var(--teal);text-decoration:none}

/* -------------------------------------------------------------- timeline -- */
.tl{position:relative;padding-left:34px;margin-top:20px}
.tl::before{content:"";position:absolute;left:11px;top:6px;bottom:6px;width:2px;background:linear-gradient(to bottom,var(--teal),var(--blue),var(--violet));opacity:.55}
.tl-item{position:relative;margin-bottom:26px}
.tl-item::before{content:"";position:absolute;left:-28px;top:7px;width:11px;height:11px;border-radius:50%;background:var(--bg);border:2px solid var(--teal)}
.tl-year{font-family:var(--f-d);color:var(--teal);font-size:.8rem;letter-spacing:.09em;font-weight:700}
.tl-item h3{margin:.15em 0 .3em;font-size:1.03rem}
.tl-item p{margin:0;color:var(--ink2);font-size:.9rem}

/* ------------------------------------------------------------- glossary -- */
.gl-nav{display:flex;flex-wrap:wrap;gap:5px;margin-bottom:22px}
.gl-nav a{border:1px solid var(--line2);border-radius:8px;width:30px;height:30px;display:flex;align-items:center;justify-content:center;font-family:var(--f-m);font-size:.8rem;color:var(--ink2)}
.gl-nav a:hover{border-color:var(--teal);color:var(--teal);text-decoration:none}
.gl-item{border-bottom:1px solid var(--line);padding:14px 0}
.gl-item b{font-family:var(--f-d);font-size:1rem}
.gl-item p{margin:.3em 0 0;color:var(--ink2);font-size:.92rem}

/* ------------------------------------------------------------------ ask -- */
.ask-box{background:var(--panel);border:1px solid var(--line2);border-radius:16px;padding:20px}
.ask-box input{width:100%;font-size:1rem;padding:13px 15px}
.ask-out{background:var(--panel2);border:1px solid var(--line);border-left:3px solid var(--teal);border-radius:12px;padding:16px;margin-top:16px}
.ask-out p{white-space:pre-wrap;margin:0 0 10px}
.ask-links{display:flex;flex-wrap:wrap;gap:7px}
.ask-links a{font-size:.78rem;border:1px solid var(--line2);border-radius:20px;padding:3px 10px}
.ask-example{display:block;padding:8px 12px;border:1px solid var(--line);border-radius:10px;margin-bottom:7px;color:var(--ink2);font-size:.88rem;cursor:pointer;background:var(--panel)}
.ask-example:hover{border-color:var(--teal);color:var(--ink);text-decoration:none}
.prompt-box{background:var(--panel);border:1px solid var(--line);border-radius:12px;padding:15px;margin-bottom:14px;position:relative}
.prompt-text{font-family:var(--f-m);font-size:.8rem;white-space:pre-wrap;color:var(--ink2);margin:8px 0 0;line-height:1.55}
[data-copy]{position:absolute;top:12px;right:12px;background:var(--panel3);border:1px solid var(--line2);color:var(--ink2);border-radius:8px;padding:4px 10px;font:inherit;font-size:.72rem;cursor:pointer}

/* ------------------------------------------------------------------ map -- */
.mapwrap{background:var(--panel);border:1px solid var(--line);border-radius:var(--radius);padding:10px;overflow:hidden}
.mapwrap svg{width:100%;height:auto}
.mapwrap path.land{fill:var(--panel3);stroke:var(--line2);stroke-width:.4}
.mapwrap circle.pin{fill:var(--teal);opacity:.82;cursor:pointer;transition:r .15s}
.mapwrap circle.pin:hover{fill:var(--amber);opacity:1}
.mapwrap circle.pin.inst{fill:var(--violet)}
#mapInfo{min-height:44px;font-size:.86rem;color:var(--ink2);padding:8px 4px}

/* ------------------------------------------------------------- guided -- */
.g-only{display:none}
body.guided .g-only{display:block}
body.guided span.g-only,body.guided a.g-only{display:inline}
.g-tip{background:color-mix(in srgb,var(--blue) 9%,var(--panel));border:1px dashed color-mix(in srgb,var(--blue) 45%,var(--line));border-radius:10px;padding:10px 13px;font-size:.85rem;color:var(--ink2);margin:0 0 14px}

/* --------------------------------------------------------------- footer -- */
.footer{border-top:1px solid var(--line);background:var(--bg2);padding:38px 18px 26px;margin-top:56px}
.f-grid{max-width:var(--max);margin:0 auto;display:grid;grid-template-columns:repeat(auto-fit,minmax(175px,1fr));gap:26px}
.f-col b{display:block;font-family:var(--f-d);font-size:.72rem;letter-spacing:.12em;text-transform:uppercase;color:var(--teal);margin-bottom:9px}
.f-col a{display:block;color:var(--ink2);font-size:.83rem;padding:3px 0}
.f-family{max-width:var(--max);margin:26px auto 0;padding-top:18px;border-top:1px solid var(--line);font-size:.8rem;color:var(--ink3)}
.f-sub{max-width:var(--max);margin:16px auto 0;display:flex;gap:9px;flex-wrap:wrap;align-items:center}
.f-langs{max-width:var(--max);margin:14px auto 0}
.f-legal{max-width:var(--max);margin:20px auto 0;padding-top:16px;border-top:1px solid var(--line);font-size:.735rem;color:var(--ink3);line-height:1.6}
.f-legal p{margin:0 0 .85em}

/* --------------------------------------------------------------- misc -- */
.breadcrumb{font-size:.78rem;color:var(--ink3);margin-bottom:12px}
.breadcrumb a{color:var(--ink3)}
.byline{font-size:.76rem;color:var(--ink3);border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:10px 0;margin:20px 0;display:flex;flex-wrap:wrap;gap:6px 20px}
.srclist{list-style:none;padding:0;margin:0;font-size:.85rem}
.srclist li{padding:7px 0;border-bottom:1px solid var(--line);color:var(--ink2)}
.srclist li:last-child{border-bottom:0}
.srclist .pub{color:var(--teal);font-size:.74rem;text-transform:uppercase;letter-spacing:.06em;font-family:var(--f-d)}
.toc{background:var(--panel2);border:1px solid var(--line);border-radius:12px;padding:13px 16px;margin-bottom:22px}
.toc b{font-family:var(--f-d);font-size:.7rem;letter-spacing:.12em;text-transform:uppercase;color:var(--ink3);display:block;margin-bottom:6px}
.toc a{display:inline-block;margin:2px 12px 2px 0;font-size:.85rem}
.relgrid{display:grid;grid-template-columns:repeat(auto-fill,minmax(230px,1fr));gap:12px}
.relbox{border:1px solid var(--line);border-radius:12px;padding:13px;background:var(--panel)}
.relbox h4{margin:0 0 7px;font-family:var(--f-d);font-size:.7rem;letter-spacing:.12em;text-transform:uppercase;color:var(--teal)}
.relbox a{display:block;font-size:.86rem;padding:3px 0;color:var(--ink)}
.relbox a:hover{color:var(--teal)}
.empty{border:1px dashed var(--line2);border-radius:12px;padding:26px;text-align:center;color:var(--ink3)}
.disc{background:var(--panel2);border:1px solid var(--line);border-radius:12px;padding:14px 16px;font-size:.82rem;color:var(--ink2);margin:22px 0}
.disc b{color:var(--amber);font-family:var(--f-d);font-size:.72rem;letter-spacing:.1em;text-transform:uppercase;display:block;margin-bottom:4px}

/* comparison matrix */
.cmp{display:grid;gap:14px;grid-template-columns:repeat(auto-fit,minmax(250px,1fr))}
.cmp-col{border:1px solid var(--line);border-radius:14px;background:var(--panel);overflow:hidden}
.cmp-col header{padding:12px 15px;background:var(--panel3);font-family:var(--f-d);font-weight:700}
.cmp-col dl{margin:0;padding:6px 15px 14px}
.cmp-col dt{font-size:.68rem;letter-spacing:.1em;text-transform:uppercase;color:var(--ink3);margin-top:10px;font-family:var(--f-d)}
.cmp-col dd{margin:2px 0 0;font-size:.88rem}
.meter{height:6px;border-radius:4px;background:var(--panel3);overflow:hidden;margin-top:5px}
.meter i{display:block;height:100%;background:linear-gradient(90deg,var(--blue),var(--teal))}

/* ideogram */
.ideo{background:var(--panel2);border:1px solid var(--line);border-radius:10px;padding:12px}
.ideo svg{width:100%;height:auto}

@media(max-width:1180px){.tagline{display:none}.searchwrap{flex-basis:190px}}
@media(max-width:980px){
  .mainnav{display:none}
  .burger{display:block}
  .split{grid-template-columns:1fr}
  .side{position:static}
  .searchwrap{flex:1 1 auto;margin-left:6px}
}
@media(max-width:620px){
  .page{padding:18px 13px 46px}
  .hero-in{max-width:100%}
  .g3,.g4,.g5{grid-template-columns:repeat(auto-fill,minmax(150px,1fr))}
  .icard,.icard-in{min-height:150px}
  .icard-in b{font-size:.9rem}
  .icard-in span{font-size:.74rem}
  .stats{grid-template-columns:repeat(auto-fit,minmax(118px,1fr))}
  .sec{margin:38px 0}
}
@media(prefers-reduced-motion:reduce){*{animation:none!important;transition:none!important}}
@media print{.topbar,.footer,.offcanvas,#genome{display:none}body{background:#fff;color:#000}}