🧭 Geführte Ansicht Neu in der Genetik? Wir erklären jeden Begriff beim Stöbern in einfacher Sprache. Dieselben Seiten, mit integrierter Hilfe.
⚡ Expertenansicht Du kennst die Biologie bereits. Nur der Inhalt – klar und kompakt, ohne zusätzliche Erklärungen. Das ist die Standardansicht.
Sprache der Benutzeroberfläche
Heller Modus
Gen · Blood
HBB
Haemoglobin subunit beta — Encodes the beta chain of adult haemoglobin; a single-letter change in it causes sickle cell disease, and reduced output causes beta thalassemia.
11p15.4bloodsickle cellthalassemia
Nur schematische Darstellung – die Proportionen der Arme sind ungefähr und die Banddetails sind nicht maßstabsgetreu. Zytogenetische Position gemäß NCBI Gene.
Was dieses Gen tut
HBB is the recipe for one of the two protein chains that make up adult haemoglobin, the molecule that carries oxygen in your blood. Change one letter of the recipe and the protein sticks to itself, causing sickle cell disease. Make too little of it and you get beta thalassemia. One gene, two very different diseases, depending on how it goes wrong.
HBB, at 11p15.4, encodes haemoglobin subunit beta. The p.Glu6Val variant (rs334) produces haemoglobin S, which polymerises when deoxygenated. Over 300 HBB variants reduce or abolish beta-globin synthesis, causing beta thalassemia. Approved editing therapy does not target HBB itself but the BCL11A enhancer, reactivating fetal haemoglobin as a functional substitute.
Sources
MedlinePlus Genetics, U.S. National Library of Medicine HBB gene ↗
Written by The CRISPR Atlas editorial teamLast updated Aug 19, 2026
Connected in the Atlas
Every entry on this site is linked to the others it relates to. These connections are part of the record, not a search result.