Giải thích đơn giản
In 2015 doctors here treated an infant with leukaemia using donor immune cells edited with TALENs, after everything else had failed. It was the first time gene-edited cells were given to a patient anywhere — years before CRISPR reached the clinic.
Tìm hiểu sâu hơn
Great Ormond Street Hospital, with University College London, administered TALEN-edited allogeneic CAR-T cells to an infant with relapsed acute lymphoblastic leukaemia in 2015 under compassionate use — the first therapeutic use of gene-edited cells in a patient.
Sources
- Science Translational Medicine · 2017
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells ↗