The definitive guide to gene editing.
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What is a chromosome?

A chromosome is one very long DNA molecule packaged with proteins; humans normally have 46, in 23 pairs.

The short answer

Your DNA is not one continuous thread but 46 separate ones, each wound up with proteins into a structure called a chromosome. They come in 23 pairs — one of each pair from each parent. Twenty-two pairs look the same in everyone; the last pair, the sex chromosomes, differ.

Chromosomes are DNA molecules complexed with histone and non-histone proteins to form chromatin. Humans typically have 46 chromosomes in 23 pairs: 22 autosome pairs and one sex chromosome pair. Each has a centromere dividing it into a short (p) and long (q) arm, and telomeres capping its ends. Cytogenetic location — the notation used on this site's gene pages, such as 11p15.4 — refers to a chromosome, an arm and a banding position.

How to read a gene address

Gene locations are written in a fixed format. HBB is at 11p15.4: chromosome 11, short arm (p), band 15, sub-band 4. The gene pages on this site draw that position on a schematic chromosome so you can see roughly where in the genome a gene sits.

Where the analogy breaks downChromosome pictures are drawn as neat banded rods with a pinched waist, but that is only what they look like during cell division. For most of a cell's life chromosomes are decondensed and tangled through the nucleus, nothing like the diagram.

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