Le CRISPR Atlas

Genes

The specific stretches of DNA that editing programmes aim at, and what each one does in the body.

19 genes in the Atlas.

19 affichés

Symbole	Nom complet	Chromosome	Ce que ça fait
HBB	Haemoglobin subunit beta	11p15.4	Encodes the beta chain of adult haemoglobin; a single-letter change in it causes sickle cell disease, and…
BCL11A	BAF chromatin remodelling complex subunit BCL11A	2p16.1	The switch that turns off fetal haemoglobin after birth — and the actual target of the world's first approved…
PCSK9	Proprotein convertase subtilisin/kexin type 9	1p32.3	A liver gene that controls how much LDL cholesterol stays in the blood — and the target of the first attempt…
TTR	Transthyretin	18q12.1	Encodes a liver protein that carries thyroid hormone and vitamin A — and which, when it misfolds, forms the…
CFTR	Cystic fibrosis transmembrane conductance regulator	7q31.2	Encodes a chloride channel in cell membranes; when it fails, secretions across the body become abnormally…
DMD	Dystrophin	Xp21.2-p21.1	The largest gene in the human genome, encoding dystrophin — the shock absorber that keeps muscle fibres…
CCR5	C-C chemokine receptor type 5	3p21.31	An immune cell surface receptor that HIV uses as a doorway — and the gene at the centre of the field's worst…
SERPINA1	Serpin family A member 1	14q32.13	Encodes alpha-1 antitrypsin, the protein that protects lung tissue from being digested by the body's own…
KLKB1	Kallikrein B1	4q35.2	Encodes prekallikrein, an upstream component of the pathway that produces the swelling of hereditary…
HTT	Huntingtin	4p16.3	Encodes huntingtin; an expanded CAG repeat in it causes Huntington's disease through a toxic gain of function.
NCF1	Neutrophil cytosolic factor 1	7q11.23	Encodes p47phox, part of the enzyme complex white blood cells use to kill bacteria — and the first gene…
BRCA1	BRCA1 DNA repair associated	17q21.31	A DNA repair gene whose loss substantially raises the risk of breast and ovarian cancer — important to gene…
BRCA2	BRCA2 DNA repair associated	13q13.1	The second major hereditary breast and ovarian cancer gene, also central to repairing double-strand DNA…
LDLR	Low-density lipoprotein receptor	19p13.2	The receptor liver cells use to clear LDL cholesterol from the blood; faults in it are the commonest cause of…
CEP290	Centrosomal protein 290	12q21.32	A large gene required for the function of the connecting cilium in photoreceptors; one deep intronic variant…
APOE	Apolipoprotein E	19q13.32	A lipid-transport gene whose ε4 variant is the strongest common genetic risk factor for late-onset…
TRAC	T cell receptor alpha constant	14q11.2	The T-cell receptor gene that must be removed to make donor immune cells safe to give to an unrelated patient.
B2M	Beta-2 microglobulin	15q21.1	A required component of MHC class I; removing it hides transplanted cells from the recipient's killer T cells.
PDCD1	Programmed cell death 1	2q37.3	Encodes PD-1, the brake tumours press to switch off attacking T cells — removed by editing so engineered…

Les symboles de gènes suivent la nomenclature HGNC ; les localisations cytogénétiques sont celles publiées par NCBI Gene et Ensembl.