CRISPR アトラス
Genes
The specific stretches of DNA that editing programmes aim at, and what each one does in the body.
19 genes in the Atlas.
19 表示中
| シンボル | 正式名称 | 染色体 | 何をするか | ★ |
|---|---|---|---|---|
| HBB | Haemoglobin subunit beta | 11p15.4 | Encodes the beta chain of adult haemoglobin; a single-letter change in it causes sickle cell disease, and… | |
| BCL11A | BAF chromatin remodelling complex subunit BCL11A | 2p16.1 | The switch that turns off fetal haemoglobin after birth — and the actual target of the world's first approved… | |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 | 1p32.3 | A liver gene that controls how much LDL cholesterol stays in the blood — and the target of the first attempt… | |
| TTR | Transthyretin | 18q12.1 | Encodes a liver protein that carries thyroid hormone and vitamin A — and which, when it misfolds, forms the… | |
| CFTR | Cystic fibrosis transmembrane conductance regulator | 7q31.2 | Encodes a chloride channel in cell membranes; when it fails, secretions across the body become abnormally… | |
| DMD | Dystrophin | Xp21.2-p21.1 | The largest gene in the human genome, encoding dystrophin — the shock absorber that keeps muscle fibres… | |
| CCR5 | C-C chemokine receptor type 5 | 3p21.31 | An immune cell surface receptor that HIV uses as a doorway — and the gene at the centre of the field's worst… | |
| SERPINA1 | Serpin family A member 1 | 14q32.13 | Encodes alpha-1 antitrypsin, the protein that protects lung tissue from being digested by the body's own… | |
| KLKB1 | Kallikrein B1 | 4q35.2 | Encodes prekallikrein, an upstream component of the pathway that produces the swelling of hereditary… | |
| HTT | Huntingtin | 4p16.3 | Encodes huntingtin; an expanded CAG repeat in it causes Huntington's disease through a toxic gain of function. | |
| NCF1 | Neutrophil cytosolic factor 1 | 7q11.23 | Encodes p47phox, part of the enzyme complex white blood cells use to kill bacteria — and the first gene… | |
| BRCA1 | BRCA1 DNA repair associated | 17q21.31 | A DNA repair gene whose loss substantially raises the risk of breast and ovarian cancer — important to gene… | |
| BRCA2 | BRCA2 DNA repair associated | 13q13.1 | The second major hereditary breast and ovarian cancer gene, also central to repairing double-strand DNA… | |
| LDLR | Low-density lipoprotein receptor | 19p13.2 | The receptor liver cells use to clear LDL cholesterol from the blood; faults in it are the commonest cause of… | |
| CEP290 | Centrosomal protein 290 | 12q21.32 | A large gene required for the function of the connecting cilium in photoreceptors; one deep intronic variant… | |
| APOE | Apolipoprotein E | 19q13.32 | A lipid-transport gene whose ε4 variant is the strongest common genetic risk factor for late-onset… | |
| TRAC | T cell receptor alpha constant | 14q11.2 | The T-cell receptor gene that must be removed to make donor immune cells safe to give to an unrelated patient. | |
| B2M | Beta-2 microglobulin | 15q21.1 | A required component of MHC class I; removing it hides transplanted cells from the recipient's killer T cells. | |
| PDCD1 | Programmed cell death 1 | 2q37.3 | Encodes PD-1, the brake tumours press to switch off attacking T cells — removed by editing so engineered… |
遺伝子記号はHGNC命名規則に従っており、細胞遺伝学的位置はNCBI GeneおよびEnsemblの公表データに基づいています。
その絞り込み条件に一致するものはありません。解除するか、 Atlas全体を検索する.